Effect of combination of metformin with B12 and folic acid on lipid profile and levels of homocysteine in adult male rabbits

The present study aims to evaluate the effects of metformin in combination with vitamin B12 and folic acid on lipid profiles serum homocysteine levels male rabbits. included twenty-four rabbits that weighed (1.5-2 kg), were divided randomly into four groups (six rabbits/group). control first group was administrated (5 ml) distilled water; second given (125g/kg B.W) plus (500 μg/kg daily, third (5g/kg daily fourth B.W), followed up for one month. results revealed a decrease final body weight gain all treated as compared group. parameter decreases significantly which four. It showed significant (metformin + B12) also glucose level increased three second, fourth, cholesterol TG have decreased G2 G3 while an increase G4 group, HDL groups. While LDL VLDL